Open AccessLocal Renin-Angiotensin System in Normal Hematopoietic and Multiple Myeloma-Related Progenitor Cells
Author(s) -
Burak Uz,
Suzin Çatal Tatonyan,
Müge Sayitoğlu,
Yücel Erbilgin,
Özden Hatırnaz Ng,
Salih Aksu,
Yahya Büyükaşık,
Nilgün Sayınalp,
Hakan Göker,
Osman Özcebe,
Uğur Özbek,
İbrahim C. Haznedaroğlu
Publication year - 2014
Publication title -
turkish journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.351
H-Index - 16
ISSN - 1300-7777
DOI - 10.4274/tjh.2013.0011
Subject(s) - cd34 , haematopoiesis , multiple myeloma , stem cell , bone marrow , progenitor cell , medicine , cancer research , hematopoietic stem cell transplantation , hematopoietic stem cell , immunology , transplantation , biology , microbiology and biotechnology
The prominent functions of the local renin-angiotensin system (RAS) in primitive hematopoiesis further support the hypothesis that local autocrine bone marrow RAS could also be active in neoplastic hematopoiesis. The aim of this study is to examine critical RAS elements in normal CD34+ hematopoietic stem cells and multiple myeloma (MM)-related progenitor cells.
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