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ObjectivesTo investigate the effect of using granulocyte-macrophage colony-stimulating factor (GM-CSF) containing culture media on embryological data and reproductive outcomes in patients with early embryonic developmental arrest.Material and MethodsRetrospective case-control study. A total of 39 patients, whose embryos were incubated with GM-CSF containing culture media due to embryonic developmental arrest in two previous IVF cycles in-between January 2016 and November 2017 at … University IVF center, were enrolled. Control group was generated among patients with first IVF attempts due to tubal factor in the same time period. All embryos in the control group were incubated with single step culture medium (without GM-CSF). For the control group selection, matching was done 1:2 ratio considering female age, body mass index, number of M-II oocyte retrieved, and number of embryo transferred (n=80).ResultsDemographic features and embryological data were comparable between two groups. Number of fertilized oocytes (2-pronuclear) was 3.7±2.0 in GM-CSF group and 3.9±2.5 in the control (p= 0.576). Overall, number of embryos transferred (1.3±0.5 vs. 1.3±0.5, respectively) and blastocyst transfer rate (67.6% vs. 59.2%, respectively; p=0.401) were similar. For the reproductive outcomes, implantation rate (32.3% vs. 33.1%, respectively; p= 0.937), clinical pregnancy rate (33.3% vs. 32.5%, respectively; p= 0.770), and live birth rate (LBR) (25.2% vs. 26.2%, respectively; p= 0.943) were similar.ConclusionUsing GM-CSF containing culture media in patients with previous two failed IVF attempts due to embryonic developmental arrest might rectify embryological data and reproductive outcomes. To make solid conclusion further randomized controlled trial is warrant.

journal of the turkish-german gynecological association

The impact of using culture media containing granulocyte-macrophage colony-stimulating factor on live birth rates in patients with a history of embryonic developmental arrest in previous in vitro fertilization cycles