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Observation: Isotretinoin is a widely used in acne treatment. It has been some side effects. This drug may rarely cause severe liver failure. Thirty-five year old woman, liver function tests significantly increased 25 days after start to using isotretionin. Other reasons that cause acute liver failure was investigated and there was not found any other reason. During follow-up period in our hospital, the bilirubin and international normalized ratio levels was not decreased. The liver biopsy showed that widespread necrosis. Finally, the patient underwent living donor liver transplantation. Isotretionin treatment may not be innocent. We recommend that the medicine be used only in wellselected patients and by monitoring.

A Case of Living Donor Liver Transplantation due to Hepatic Failure Cause of Isotretinoin Therapy