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Although the incidence of gastric cancer decreases, it is still one of the most common causes of cancer mortality due to late diagnosis. Early diagnosis and treatment may be beneficial for preventing diseases, survival, and cost-effectiveness. Therefore, identification and follow-up of patients who are under the risk of gastric cancer increase the success of treatment. Homeostasis of gastric mucosa is sustained by prostaglandins (1). Cyclooxygenase-2 (COX2) is expressed at gastric mucosa which is low in healthy tissue and high in the granulation tissue DOI: 10.4274/gulhane.galenos.2020.793 ORIGINAL ARTICLE

Can increased or decreased COX2 and P21 expression be used in illness monitoring of gastric cancer and its potential precursor lesions?