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With the ongoing outbreak of 2019 novel coronavirus (COVID-19) in December 2019, the diagnosis and treatment of this disease are critically important to clinicians. Presently, chest computed tomography (CT) and nucleic acid test are still the two most important auxiliary examinations in the COVID-19 diagnosis, according to the constantly updating diagnosis and treatment standards. The chest CT imaging of the general population with COVID-19 was described as bilateral pulmonary parenchymal ground-glass opacity (GGO) and consolidation in earlier published papers (1). A few cases about pregnant women with COVID-19 had been reported. Here, we present the characteristics of CT changes, from onset to recovery, in the lungs of a pregnant woman with COVID-19, which may help with the future diagnosis and treatment of this disease. A 25-year-old woman who was 35 weeks and 1 day pregnant was admitted to a local hospital on February 9, 2020, presenting with a history of fatigue and mild dry cough for 3 days. She developed fever, as evidenced by an axillary temperature of 38.3°C on the same day as her hospital admittance. On examination, the routine blood test revealed a normal leukocyte count (6.67×109 cells/L; reference range: 4-10×109 cells/L), elevated neutrophil ratio (86.60%; reference range: 45–75%), and reduced lymphocyte count (0.71×109 cells/L; reference range: 0.8-4.0×109 cells/L). Although the patient had not visited Wuhan in the previous 14 days and had no history of exposure to any confirmed COVID-19 patients in local areas, the obstetrician took a throat swab to test for the presence of severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). A chest radiograph was also performed, and the results revealed patchy increased density with unclear edges in the middle and upper fields of the left lung. Chest CT was not performed on that day because she was concerned about the associated radiation exposure to the fetus. On February 11, 2020, the nucleic acid test of the patient showed a positive result. The patient was referred to our hospital. Chest CT was performed at this time, and the results revealed obvious GGO regions with indistinct borders in both lungs (Figure 1a, b). Termination of pregnancy was performed by cesarean section after admission because of fetal distress suggested by fetal heart monitoring. To investigate whether COVID-19 is possible through maternal-fetal vertical transmission, we collected the amniotic fluid, cord blood, placenta, neonatal serum, neonatal throat swab, and neonatal anal swab for the nucleic acid test, and all of which showed negative results. The patient received antibiotic therapy (sodium piperacillin methimazole ba temple), antiviral treatment (interferon), immune enhancement (thymopentin), and uterotonic (applied after the operation). The temperature of the patient remained normal, and the symptoms included dry cough and fatigue, which disappeared on the first day after the operation. On February 16, reexamined chest CT revealed that the regions of lung infection were significantly larger than that on admission (Figure 1c, d); specifically, there was an increased range of ground-glass density patches, and partial consolidation was observed as well as a small range of bilateral pleural effusion. In response to this finding, anti-infective therapy was intensified by commencing treatment with an additional antibiotic (moxifloxacin) and glucocorticoid. The third and final chest CT, performed on February 20, 2020, showed significant reductions in the lesion area and sites (Figure 1e, f). In addition, two consecutive nucleic acid tests from throat swabs showed negative results. The patient was transferred to the rehabilitation ward for observation on February 21. Written informed consent was obtained from the patient. SARS-CoV-2 is a novel coronavirus belonging to the β genus, and its genetic characteristics are significantly different from those of SARS-CoV and Middle East respiratory syndrome coronavirus (2). The bat is speculated to be the intermediate host of SARS-CoV-2. The main transmission routes of SARS-CoV-2 include air, droplets, aerosol, and contact, and the outstanding characteristics of the disease caused by this virus are human-to-human transmission and family

Chest CT Findings in a Pregnant Patient with 2019 Novel Coronavirus Disease