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In grade 2 and grade 3 glial tumors, pathological diagnosis is not possible only with histopathological examination. For the diagnosis of oligodendroglial tumor 1p / 19q codeletion, fort he diagnosis of astrocytic tumor ATRX and p53 mutation should be determined. PDGFRA amplification is more common in high grade glial tumors and is not included in the class of glial tumor with intermediate grade. The presence of IDH mutation and 1p / 19q codeletion in glial tumors is associated with good prognosis.

balkan medical journal/balkan medical journal

The Applicability of Haarlem Integrated Diagnostic System in Diffuse Glial Tumors and The Role of PDGFRA Amplification as a Marker of Recurrence and Prognosis