Open AccessDetection of Zika Virus Infection in Myanmar
Author(s) -
Mya Myat Ngwe Tun,
Aung Kyaw Kyaw,
Saw Wut Hmone,
Shingo Inoue,
Corazon C. Buerano,
Aung Min Soe,
Meng Ling Moi,
Daisuke Hayasaka,
Hlaing Myat Thu,
Futoshi Hasebe,
Kyaw Zin Thant,
Kouichi Morita
Publication year - 2018
Publication title -
american journal of tropical medicine and hygiene
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.015
H-Index - 151
eISSN - 1476-1645
pISSN - 0002-9637
DOI - 10.4269/ajtmh.17-0708
Subject(s) - zika virus , virology , dengue fever , dengue virus , flavivirus , asymptomatic , transmission (telecommunications) , antibody , virus , biology , medicine , immunology , pathology , engineering , electrical engineering
Zika virus (ZIKV), an emerging mosquito-borne flavivirus, causes a dengue-like infection that has recently caught global attention. The infection, which also includes some birth defects, has been documented in the Americas, Pacific Islands, and some parts of Africa and Asia. There are no published reports on local ZIKV transmission in Myanmar. In this study, a total of 462 serum samples from patients and asymptomatic persons were collected in Myanmar from 2004 to 2017. They were analyzed for ZIKV infection by immunoglobulin M capture enzyme-linked immunosorbent assay (ELISA), immunoglobulin G indirect ELISA, neutralization test, real-time polymerase chain reaction (PCR), and conventional PCR. Our study confirmed ZIKV infection in 4.9% of patients with clinical dengue symptoms and in 8.6% of persons who were asymptomatic. This is the first report on ZIKV infection in Myanmar and it suggests the occurrence of ZIKV infection in two geographically distinct sites in this country since at least 2006.
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