Open AccessReversibility of Retinal Microvascular Changes in Severe Falciparum Malaria
Author(s) -
Richard J. Maude,
Hugh Kingston,
Sonia Joshi,
Sanjib Mohanty,
Saroj K. Mishra,
Nicholas J. White,
Arjen M. Dondorp
Publication year - 2014
Publication title -
american journal of tropical medicine and hygiene
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.015
H-Index - 151
eISSN - 1476-1645
pISSN - 0002-9637
DOI - 10.4269/ajtmh.14-0116
Subject(s) - cerebral malaria , retinal , malaria , retinopathy , blood–retinal barrier , medicine , retina , plasmodium falciparum , pathogenesis , ophthalmology , protozoal disease , pathology , biology , diabetic retinopathy , neuroscience , endocrinology , diabetes mellitus
Malarial retinopathy allows detailed study of central nervous system vascular pathology in living patients with severe malaria. An adult with cerebral malaria is described who had prominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of which resolved on recovery. Additional study of these features and their potential role in elucidating the pathogenesis of cerebral malaria is warranted.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom