Open AccessProspective Cohort Study with Active Surveillance for Fever in Four Dengue Endemic Countries in Latin America
Author(s) -
Gustavo H. Dayan,
José Luis Arredondo-Garcı́a,
Gabriel Carrasquilla,
Carmen Deseda,
Reynaldo Dietze,
Kléber Giovanni Luz,
Maria Selma Neves da Costa,
Rivaldo Venâncio da Cunha,
Luís Rey,
Javier Graus Morales,
Humberto Reynales,
María Consuelo Miranda,
Betzana Zambrano,
Enrique Rivas,
Pedro Garbes,
Fernando Noriega
Publication year - 2015
Publication title -
american journal of tropical medicine and hygiene
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.015
H-Index - 151
eISSN - 1476-1645
pISSN - 0002-9637
DOI - 10.4269/ajtmh.13-0663
Subject(s) - dengue fever , latin americans , medicine , cohort , environmental health , prospective cohort study , geography , virology , political science , law
To prepare for a Phase III dengue vaccine efficacy trial, 20 investigational sites were selected for this observational study to identify dengue infections in a closed cohort (N = 3,000 children 9-16 years of age). Of 255 acute febrile episodes experienced by 235 children, 50 (21.3%) were considered serologically probable dengue, and 18 (7.7%) were considered virologically confirmed (i.e., dengue NS1 antigen positive) dengue cases. Considering the disease-free and at-risk period from study start to onset of symptoms, the overall incidence density of acute febrile episodes was 17.7 per 100 person-years of follow-up, ranging from 15.3 in Colombia to 22.0 in Puerto Rico. This study showed that all sites were capable of capturing and following up acute febrile episodes within a specific timeframe among the established cohort and to detect dengue cases.
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