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Since 1(2-oxocyclopentyliden) -2-alkanols (1) showed enhanced bio-antimutagenic activity against UV-induced mutagenic Escherichia coli WP2 B/r trp, 1(2-oxocyclopentyliden) -3-oxaand 3-thiaalkanes (4 and 7) and 10(2-oxocyclopentyliden)-8-oxadecanol (5) were synthesized, and their bio-antimutagenic and bactericidal activity were measured. 10(2Oxocyclopentyliden)-8-oxadecanol (5) showed weak activity (AD50, 95.5 ƒÊ g/ml), while 1(2oxocyclopentyliden)-3-oxanonane (4a) and 1(2-oxocyclopentylidene) -3-thianonane (7) showed bactericidal activity (ID50, 7.5 and 11.0 ƒÊg/ml, respectively).

biocontrol science

Bio-antimutagenic and Microbicidal Activities of 1-(2-Oxocyclopentyliden)-3-Oxadecane and the Derivatives against Mutagenic Escherichia coil WP2 B/r trp.