English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

According to the 2014 American Heart Association/ American College of Cardiology/Heart Rhythm Society guideline, symptomatic drug-refractory paroxysmal atrial fibrillation (PAF) is a class I level A indication for catheter ablation. The cornerstone of ablation therapy for PAF is pulmonary vein isolation (PVI) . When performed by the conventional radiofrequency (RF) ablation method, PVI is achieved by heating the tissue for creation of contiguous, transmural point-by-point lesions . However, RF-based PVI is time-consuming, and cryoballoon ablation (CBA) was developed to shorten and simplify the procedure. With CBA, transmural lesions are created by freezing the tissue, and a recent clinical trial showed the safety and efficacy of CBA for PAF to be equal to that of RF ablation (RFA) . A previous study showed the posterior left atrial (LA) wall area isolated by CBA to be wide and antral, and the resulting debulking of this area, in addition to discrete PVI, was thought to explain, at least in part, the efficacy of CBA. However, a more recent study showed the PV antral area isolated by CBA to be significantly smaller than the circumferential PV area isolated by RFA. The intrinsic cardiac autonomic nervous system (i.e., the ganglionated plexi [GPs]) has been thought to contribute to the AF substrate and specifically to the initiation and persistence of AF. The LA GPs are located within the epicardial fat pads at the LA/PV junction and adjacent LA antrum, and therefore, RF-based circumferential PVI also ablates the LA GPs. In the retrospective study described herein, we compared the effects of CBA and RFA on the LA GPs.

Effect of Cryoballoon Ablation vs. Radiofrequency Ablation on Left Atrial Ganglionated Plexi in Patients with Atrial Fibrillation