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We preliminarily studied time-dependent components of the cycloplegic action of atropine by use of a quasi-static mesurement of accommodation.Seven eyes of seven children aged 5 to 12 years were measured; five eyes of five esotropes without amblyopia and two sound eyes of two unilateral amblyopes.An infrared optometer with computerized control which could continuously measure the accommodation was adopted.Before and 3, 5, 7 and 10 days after the initial medication of 1% solution of atropine sulfate which was instilled twice daily for ten days, measurements were performed. Furthermore 0, 2, 4, 6 and 8 weeks following the final adminstraction, the children were also examined. From each quasi-static measurement, an objective accommodation amplitude was obtained. Accommodation was completely paralyzed at the seventh and tenth days from the begining of the medication, and fully recovered from cycloplegia at the fourth or the eighth week following the final instillation.We conclude that, in order to obtain complete cyclolegia, seven days medication of atropine is necessary when it is instilled twice a day and that four to eight weeks are needed to wash it out entirely.

A quasi-static study of atropine cycloplegia in children (A preliminary report). The duration for its maximum effect and complete vanishment.