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【Purpose】To evaluate the repeatability of crystalline lens decentration and tilt measurements obtained by anterior segment optical coherence tomography (AS-OCT) in normal phakic eyes. 【Subjects and Methods】Twenty eyes of ten visually normal subjects (average age, 29.8 ± 11.5 years) were enrolled. Using AS-OCT, two examiners (Examiner A and B) measured the lens decentration and tilt three times for each eye. The amounts of the lens decentration and tilt were analyzed based on crystalline lens morphology. The measurements by the two examiners were compared using the Bland-Altman plot. Both intra-examiner and inter-examiner correlation coefficients (ICC) were calculated. Distributions of the vector quantities for the two eyes by the two examiners were obtained and the average values were compared. Spearman rank correlation coefficient was applied to analyze the correlation coefficient of the decentration and tilt directions between the examiners. 【Results】The measurements (mean ± standard deviation) of decentration were 0.23 ± 0.02 mm for the right eye and 0.24 ± 0.02 mm for the left eye by both examiners. The measurements of tilt by examiner A and B were 3.8 ± 0.24 ° and 3.8 ± 0.21 ° for the right eye, and 4.1 ± 0.24 ° and 4.2 ± 0.25 ° for the left eye, respectively. No significant difference in the measurements was observed between the two examiners (P > 0.05). The average values of decentration and tilt by both examiners had a difference less than 0.01 mm (decentration) and 0.1 ° (tilt) for both eyes with 95% Confidence Intervals of ± 0.1 mm and ± 0.5 ° for both eyes. The intraand inter-examiner correlation coefficients were 0.9 or higher for both eyes. No significant difference in the average vector quantities of decentration and tilt for the left and right eyes was seen between both examiners (P > 0.05). The inter-examiner correlation coefficients of the decentration direction were r = 0.94 for the right eye and r = 0.99 for the left eye with a maximum inter-examiner difference of 22 ° . The inter-examiner correlation coefficients of the tilt direction were r = 0.99 for the right eye and r = 0.86 for the left eye with a maximum inter-examiner difference of 10 ° . 【Conclusion】Measurements of the crystalline lens decentration and tilt by AS-OCT appeared to have good repeatability in young normal phakic eyes and were considered useful for clinical use.

Repeatability of Measurements of Crystalline Lens Decentration and Tilt by Anterior Segment Optical Coherence Tomography