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Peritumoral  brain edema is a common complication of meningiomas. It is believed that  vascular endothelial growth factor (VEGF), as an angiogenic factor, plays a  vital role in edema formation. Aquaporin-4 (AQP4) is a small integral membrane  protein that regulates water in the normal brain. However, the expression of  AQP4 and its relationship to VEGF in edematous meningiomas are not well known.  We studied tumor specimens of 59 human supratentorial meningiomas. Western blot  analysis was used to detect the expression of AQP4, and double-labeling  immunofluorescence histochemical staining was performed to determine the  relationship between AQP4 and VEGF. The AQP4 expression was significantly  higher in the edema group, in which the protein level was correlated with the  extent of edema. Greater VEGF expression was also observed in the edema group,  and a relationship between AQP4 and VEGF was found. We conclude that AQP4 is  involved in peritumoral brain edema formation in meningiomas and is also  closely related to the expression of VEGF.

Expression of aquaporin-4 in human supratentorial meningiomas with peritumoral brain edema and correlation of VEGF with edema formation