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The plants Brosimum gaudichaudii (inharé) and Caesalpinia ferrea (jucá) are widely distributed throughout Brazil and are considered medicinal. Inharé has been popularly used as a blood purifier, for the treatment of skin and vitiligo, while jucáis considered analgesic, anti-inflammatory and anticancer. These therapeutic properties have been attributed to phytochemicals such as coumarins, flavonoids and tannins. However, the mechanisms of action of most of these phytochemicals have not yet been fully elucidated and they may compromise human health. Consequently, the evaluation of the genotoxic effect of these plant extracts is fundamental for the determination of safe doses for human consumption. We evaluated the genotoxic effect of various concentrations of extracts of B. gaudichaudii and C. ferrea using comet assay of erythrocytes from Astyanax sp. exposed in vivo. In the comet assay indicated the tail migration of DNA increased

genetics and molecular research

Research Article Genotoxicity of &lt;i&gt;Brosimum gaudichaudii&lt;/i&gt; (Moraceae) and &lt;i&gt;Caesalpinia ferrea&lt;/i&gt; (Fabaceae) in &lt;i&gt;Astyanax&lt;/i&gt; sp. (Characidae) based on a comet assay