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We determined whether the blood pressure response to losartan in an older Chinese population with essential hypertension was associated with apelin gene polymorphisms. We genotyped the -1860T&gt;C polymorphism of the apelin gene in a case-control study of 222 patients with hypertension and 250 controls. Following 24 weeks of treatment with losartan (50 mg/day), reductions in systolic blood pressure were significantly different among the additive (CT vs CC vs TT), dominant (TT vs CC/CT), and recessive models (CC vs CT/TT; all P &lt; 0.05) in women but not in men. In the additive model, the TT group showed the greatest reductions in systolic BP (23 ± 10 mmHg) after treatment. The CT group showed greater reductions in systolic BP (21 ± 11 mmHg) compared to the CC group (8 ± 3 mmHg) (P &lt; 0.05). The reductions in systolic BP of the TT and CT/CC groups were 23 ± 10 and 19 ± 10 mmHg, respectively. The reductions in systolic BP of the CC and TT/CT groups were 8 ± 3 and 21 ± 10 mmHg, respectively. After adjustment for confounding factors, quantitative trait analysis with a general linear model showed that the female patients with TT genotype showed greater reductions in systolic blood pressure after 24 weeks of treatment compared to the patients with the C allele (P &lt; 0.05). The apelin -1860T&gt;C genotype may play an important predictive role in the response to losartan in hypertensive women.

Apelin polymorphism predicts blood pressure response to losartan in older Chinese women with essential hypertension