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We conducted a case-control study to investigate the association between IL-6 -174 G&gt;C and -572 C&gt;G polymorphisms and the risk of coronary artery disease (CAD). We genotyped IL-6 -174 G&gt;C and -572 C&gt;G in 402 patients with CAD and 402 control individuals. IL-6 -174 G&gt;C (rs1800795) and -572 C&gt;G (rs1800796) alleles were detected by polymerase chain reaction-restriction fragment length polymorphism. Patients with CAD were more likely to have a smoking habit, diabetes, and hypertension, a high level of triglycerides, and low levels of total cholesterol and high- and low-density lipoprotein cholesterol. Multivariate regression analyses showed that subjects carrying the IL-6 -174CC genotype had a small but significant increased risk of CAD (P = 0.004). Those carrying the IL-6 -174 G&gt;C polymorphic variant had a slightly increased risk of CAD in both dominant and recessive models. However, we did not find significant association between the IL-6 -572 C&gt;G polymorphism and risk of CAD. Moreover, a significant interaction was found between the IL-6 -174 G&gt;C polymorphism, gender, and smoking habit. Our study, therefore, demonstrated that the IL-6 -174 G&gt;C polymorphism is correlated with CAD risk, and that this polymorphism shows interactions with both gender and smoking.

Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease