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We  investigated the effects of cadmium on lung cell DNA in immature mice. The mice  were randomly divided into four groups: control group, low-dose group (1/100 LD(50)),  middle-dose group (1/50 LD(50)),  and high-dose group (1/25 LD(50));  they were supplied with cadmium chloride or control water for 40 days. Lung  cells collected from sacrificed mice were used to evaluate the extent of DNA  damage by comet assay. The ratio of tailing cells, DNA tail length, DNA comet  length, DNA tail moment, DNA olive tail moment, and percentage of DNA in the  comet tail were measured. The rate of tailing lung cells exposed to cadmium  increased significantly; the low-concentration group had significantly (P &lt;  0.05) higher rates, and the middle- and high-concentration groups had higher (P  &lt; 0.01) rates compared to the control. DNA tail length, DNA comet length,  DNA tail moment, and DNA olive tail moment all increased with the increase in  cadmium doses, but compared with those of the control group, no significant  differences in low-dose group were found (P &gt; 0.05), and the differences in  middle- and high-dose groups were all highly significant (P &lt; 0.01). The  degree of DNA damage also increased with the increase of the cadmium  concentrations. We conclude that cadmium significantly increases DNA damage in  lung cells of immature mice in a dose-dependent manner.

Damaging effects of water-borne cadmium chloride on DNA of lung cells of immature mice