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A  number of studies have pointed to the association of BDNF (brain-derived  neurotrophic factor) and DARPP-32 (dopamine- and cAMP-regulated  phosphoprotein, 32 kDa) with schizophrenia. The purpose of this study was to  determine whether these two genes are involved in the pathogenesis of  schizophrenia in the Malay population. Two single nucleotide polymorphisms  Val66Met of BDNF, -2036C&gt;G and g.1238delG of DARPP-32 were  genotyped in the Malay population in 200 patients with schizophrenia and 256  healthy controls. Analysis of allele and genotype frequencies in these two  groups revealed no significant association of BDNF or DARPP-32 polymorphisms  with schizophrenia in Malays. This is the first such association study in the  Malay population.

BDNF and DARPP-32 genes are not risk factors for schizophrenia in the Malay population