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Pathogen infection in plants is often limited by a  multifaceted defense response triggered by resistance genes. The most prevalent  class of resistance proteins includes those that contain a nucleotide-binding  site-leucine-rich repeat (NBS-LRR) domain. Over the past 15 years, more than 50  novel NBS-LRR class resistance genes have been isolated and characterized; they  play a significant role in activating conserved defense-signaling networks.  Recent molecular research on NBS-LRR resistance proteins and their signaling  networks has the potential to broaden the use of resistance genes for disease  control. Various transgenic approaches have been tested to broaden the disease  resistance spectrum using NBS-LRR genes. This review highlights the recent  progress in understanding the structure, function, signal transduction ability  of NBS-LRR resistance genes in different host-pathogen systems and suggests new  strategies for engineering pathogen resistance in crop plants.

Review Functional characterization and signal transduction ability of nucleotide-binding site-leucine-rich repeat resistance genes in plants