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Resveratrol  (RSV) has a beneficial role in the prevention of diabetes and alleviates some  diabetic complications, such as cardiomyopathy. We investigated  cyclooxygenase-1 (COX-1), COX-2, nuclear factor κB (NF-κB), matrix metalloproteinase-9 (MMP-9), and sirtuin 1  (SIRT1) mRNA expression levels in heart tissue after RSV treatment in  streptozotocin (STZ)-induced diabetic rats. After induction of chronic diabetes  with STZ, 10 mg RSV/kg per day was administered to DM and DM+RSV groups for  four weeks. At the end of the experiment, all rats were sacrificed and heart tissues  were stored at -80°C; mRNA expression levels of COX-1, COX-2, NF-κB, MMP-9, and SIRT1 genes were  analyzed with quantitative real-time PCR. We did not find any significant  effect of RSV on MMP-9, COX-1, COX-2, or NF-κB mRNA levels among the groups. However, SIRT1 mRNA  levels decreased in the DM group compared to controls and increased in the  DM+RSV group when compared to the DM group. SIRT1 is activated by RSV treatment  in diabetic heart tissue. Activation of SIRT1 by RSV may lead to a new  therapeutic approach for diabetic heart tissue. We conclude that RSV treatment  can alleviate heart dysfunction by inhibiton of inflammatory gene expression  such as SIRT1.

genetics and molecular research

The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats