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Glutathione-S-transferase  P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway.  One of the common functional polymorphisms of GSTP1 is A→G at nucleotide  313, which results in an amino acid substitution (Ile105Val) at the substrate  binding site of GSTP1 and reduces catalytic activity of GSTP1. To investigate  the GSTP1 Ile105Val genotype frequency in prostate cancer cases in the  Kashmiri population, we designed a case-control study, in which 50 prostate  cancer cases and 45 benign prostate hyperplasia cases were studied for GSTP1  Ile105Val polymorphism, compared to 80 controls taken from the general  population, employing the PCR-RFLP technique. We found the frequency of the  three different genotypes of GSTP1 Ile105Val in our ethnic Kashmir  population, i.e., Ile/Ile, Ile/Val and Val/Val, to be 52.4, 33.3 and 14.3%  among prostate cancer cases, 48.5, 37.5 and 14% among benign prostate  hyperplasia cases and 73.8, 21.3 and 5% in the control population,  respectively. There was a significant association between the GSTP1 Ile/Val genotype  and the advanced age group among the cases. We conclude that GSTP1 Ile/Val polymorphism  is involved in the risk of prostate cancer development in our population.

Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population