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Gastrointestinal stromal tumor (GIST) represents the most common kind of mesenchymal tumor that arises from the alimentary tract. Tumors arising from the first and the second part of the duodenum (DI and DII, respectively) can be wrongly diagnosed as pancreatic mass. We report a case of a 58-year-old male patient with the history of vomiting just after eating, loss of appetite, lethargic and weight loss for 25 days. CT scan of abdomen and pelvis showed a soft tissue mass with slight heterogeneous enhancement at the region of the uncinate process of the head of pancreas and (MPR) on CT enhanced showed the closely attached mass to the head of the pancreas. On operative exploration, the mass was found to be originated from duodenum. Then, surgical resection of the duodenal tumor was performed by wedge resection successfully. Postoperative laboratory diagnosis was “low risk” duodenal gastrointestinal stromal tumor.

Case Report of Duodenal Gastrointestinal Stromal Tumor Masquerading a Pancreatic Head Tumor