English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The N-methyl D-aspartate receptor (NMDAR) is composed of several subunits. Among them, the N2B is of interest, given its dominance in early develop-ment and its significant impact on neuronal channel functioning and the formation or maintenance of cellular architecture. NMDAR-N2B, also named GRIN2B, has been implicated in broad neuro-psychiatric conditions. However, the genetic impact on cortical oscillation in the human brain is still unclear. This study examined the modulatory ef-fects of a silent mutation C2644T polymorphism on the EEG oscillation. Blood samples were collected and resting state eyes-closed EEG signals were re-corded in 256 young healthy females, stratified into three groups according to genotypes C/C, C/T and T/T. The values of the mean power of 18 electrodes across delta, theta, alpha, beta and gamma frequencies were analyzed. Between-group statistics were determined by ANOVA and independent t-test; and a global trend of regional power was quantified by non-parametric analyses. No significant be-tween-group differences were noticed with the statis-tical threshold after Bonferroni correction. At less conservative threshold of P < 0.01, C/T group had higher regional power at sparse electrode-frequency pairs in posterior brain regions. However, a consis-tent global trend was noticed wherein the C/T group possessed higher EEG powers, regardless of spectral bands. Nonparametric analyses confirmed this ob-servation. Our results implied that the heterozygous group of GRIN2B C2744T was associated with higher neural synchronization during relaxation, which may be relevant to the impact of GRIN2B in early devel-opment and the inverted-U-shaped response in the NMDA system

The influence of NMDA receptor 2B subunit (GRIN2B) on cortical electrical oscillation