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In this study, we aimed to observe the cytotoxicity, antioxidant and anti-inflammatory activity of Rhododendron brachycarpum extract (RbE) in RAW 264.7 macrophage cell in vitro and the anti-inflammatory or soothing effect of RbE formulated cream (Multicalm-RHTM) on experimentally induced acute irritated skin in healthy subjects in vivo. In vitro study revealed that RbE significantly inhibited NO and ROS generation in a dose dependent manner without cytotoxicity. In clinical test, Multicalm-RHTM cream siginificantly reduced the SLS-enduced erythema after D5 compared to that of placebo. Overall, it can be concluded that the RbE is a non-cytotoxic, antioxidant and anti-irritant agent which can be used as a potent functional ingredient in cosmetics. Likewise, the in vivo clinical study shows that Multicalm-RHTM cream which contains 3% RbE can be used as an effective skin soothing agent.

ji shu yu tou zi

Evaluation of Antioxidant and Anti-Inflammatory Effect of &amp;lt;i&amp;gt;Rhododendron brachycarpum&amp;lt;/i&amp;gt; Extract Used in Skin Care Product by &amp;lt;i&amp;gt;in Vitro&amp;lt;/i&amp;gt; and &amp;lt;i&amp;gt;in Vivo&amp;lt;/i&amp;gt; Test