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Background:  Autosomal  dominant  polycystic \ud kidney disease is a condition mainly character-\ud ized by the progressive development and enlar- \ud gement of cysts in each kidney. In this process a \ud high rate of proliferation and apoptosis of tubu-\ud lar  cells  has  been  documented  and  interpreted \ud as a futile attempt of tissue repair. In considera-\ud tion of the role of stem cells in reparative proc-\ud esses  we  investigated  the  presence  and  local-\ud ization  of  CD133  +  CD24+  renal  progenitors  in \ud renal  ADPKD  tissue  and  cells.  Methods:  Two \ud normal  kidneys  and  two  ADPKD  kidneys  were \ud examined. CD133 and CD24 expression was in-\ud vestigated  by  confocal  microscopy  and  immu- \ud noblotting. Furthermore cystic isolated cells and \ud cultured  immortalized  cells  were  characterized. \ud Results: CD133 and CD24 have the same local- \ud ization in ADPKD tissues and in normal kidneys: \ud expression is restricted to a subset of epithelial \ud cells (PEC) of Bowman’s capsule and to tubular \ud cells  in  a  focal  and  segmental  pattern.  Further- \ud more, in ADPKD tissue, cysts diffusely express \ud CD133  and  CD24.  According  to  a  quantitative \ud analysis in ADPKD tissue CD133 + CD24 + cells \ud are statistically more expressed in tubules (p < \ud 0.001)  and  less  expressed  in  the  Bowman’s \ud capsule  (p  =  0.0016)  compared  to  the  same  lo- \ud calizations in control tissue. Conclusions: CD133 \ud and CD24 antigens, typically expressed by renal \ud epithelial  progenitors,  are  more  expressed  in \ud ADPKD tubules and highly expressed in ADPKD \ud cysts.  Whether  CD133  and  CD24  expression \ud would  signify  renal  progenitor  recruitment  or \ud alternatively an expression pattern of the dedif- ferentiation of ADPKD cells remains unclear

CD133 and CD24 expression in renal tissue of patients affected by autosomal dominant polcystic kidney disease