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Objective: Analysis of stress response of newborns born vaginally assisted compared to those born by caesarean section scheduled at birth and then 15 days to 2 months of life. The methodology is based on: 1) The neonatal period, the analysis of cortisol levels in the blood of the umbilical artery by Radio-Immuno-Assay, 2) At the age of 15 days and two months, evaluation of the intensity of the pain response to vaccine act using DAN scores. The results of the first part of the study showed that both groups were comparable regarding maternal and neonatal characteristics except for gestational age and BMI with values of 39.9 SA respectively for channels bass, SA for 38.6 and 28.03 cesareans for low tract and 29.1 cesareans. The average values of cortisol were 403.4 nmol/L ± 260.90 for bass tracks and 117.1 ± 63.90 for caesarean sections. The difference is statistically significant with a p < 0.00001. The results of the second part showed that there are significant differences by comparing post-vaccination pain scores as well after BCG to 15 days of life, after Infanrix HIB polio at two months of life. p is respectively 0.0016 at 15 days of life and 0.0001 at two months. In conclusion, newborns’ extracts assisted vagina to live such stress at birth; their immediate response to stress is much higher than those born by high way before the beginning of work, and their pain response is more intense in 15 days and two months of life.

Influence of Mode of Delivery on the Stress Response in Infants