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Objective: The purpose of this study was to determine how the slice thickness reconstruction influences quantitative perfusion CT parameters. Materials and Methods: Eighteen patients with cancer (15 non-small-cell lung cancer, 2 rectal cancer and 1 renal cancer) were examined prospectively with multidetector row CT. A 90-second perfusion study was performed after intravenous bolus injection of contrast material. Blood flow, blood volume, mean transit time and permeability-surface area product were determined at three different slice thickness reconstruction (1.25, 2.5 and 5 mms) both in tumors and in paraspinal muscle. Mean values, limits of agreement between measurements and within-subject coefficient of correlation were obtained for these thicknesses. Results: Mean ± standard deviation BF, BV, MTT and PS in lesions were 118.7 ± 117.9 mL/min/100g tissue, 8.2 ± 8.2 mL/100g tissue, 7.5 ± 5.4 seconds and 10.3 ± 7.2 mL/min/100g tissue respectively at1.25 mmslice thickness; 116.1 ± 115.7 mL/min/100g tissue, 7.8 ± 8.7 mL/100g tissue, 7 ± 4.5 seconds and 10.4 ± 7.5 mL/min/100g tissue at 2.5 mms; and 119.6 ± 115.7 mL/min/100g tissue, 7.8 ± 8.8 mL/100g tissue, 5.4 ± 3.4 seconds and 9.6 ± 7.5 mL/min/100g tissue at 5 mms. Differences between means for different slice thickness where relatively small in all parameters (<15%) except in MTT where difference was up to 37%. 95% limits of agreement were worse when comparing more different slice thicknesses (e.g. 1.25 vs 5 mms) than when comparing more close slice thicknesses (1.25 vs 2.5 mms or 2.5 vs 5 mms). Conclusions: There is a significant variability in perfusion parameter measurements at different slice thickness reconstruction, particularly in MTT. The more close together the slice thicknesses were, the smaller was the variability.

Effect of Slice Thickness Reconstruction on Quantitative Vascular Parameters in Perfusion CT