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A new green synthesis and anti-tumor activity of the series of bis (3-arylimidazolidinyl-1) methanes 1 - 6 are described.  The compounds were synthesized from the corresponding N-arylethylenediamine and trioxane as source of formaldehyde  and the reactions were performed in heterogeneous phase catalyzed by an acidic ion-exchange resin (Amberlyst  15). The compounds were tested with the Sulforhodamine B assay according to the protocol of the National Cancer Institute  for several cell lines. The results were expressed as percentage inhibition of growth cell in comparison with the  full growth of the cells without treatment. Cytotoxicity on normal cells using the Annexing-PI staining and flow cytometry  has been evaluated. The parent compound, bis(3-phenylimidazolidinyl-1)methane 1 and the monohalogenated  derivatives 4-chlorophenyl 3 and 3-bromophenyl 5 showed antineoplastic activity, 60%, 82% and 89% inhibition  growth cell respectively on the human colon cell line (HCT116). The 4-tolyl derivative 6 presented inhibitory activity (73%  inhibition of growth cell) on human lung adenocarcinoma cell line (A549) and 62% on human mammary cell line MCF-7.Fil: Caterina, Maria Cristina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Quimica Orgánica; Argentina;Fil: Perillo, Isabel Amalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Quimica Orgánica; Argentina;Fil: Villalonga, Ximena Soledad. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Estudios Farmacologicos y Botánicos; Argentina;Fil: Amiano, Nicolás Oscar. Universidad de Buenos Aires. Facultad de Medicina. Cat.de Farmacología; Argentina;Fil: Payés, Cristian. Universidad de Buenos Aires. Facultad de Medicina. Cat.de Farmacología; Argentina;Fil: Sanchez, Mercedes Leonor. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Estudios Farmacologicos y Botánicos; Argentina;Fil: Salerno, Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Química Orgánica;Argentina

New Green Synthesis and Antineoplastic Activity of Bis (3-Arylimidazolidinyl-1) Methanes