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Background: There is very limited data available about the epidemiology trial on chronic diseases comprehensive intervention. The aim of this study was to assess the effect of comprehensive intervention on chronic diseases in Baoji and provide basis for the improvement of chronic diseases intervention measures. Methods: Using four stages stratified random sampling method, comprehensive intervention measures were implemented on intervention group (575 individuals) respectively aimed at three crowds of whole population, high risk population and chronic diseases patients. The control group (782 individuals) did not receive special treatment. Two groups were evaluated effect after one year observation. Results: The chronic diseases prevalence rate of whole population in intervention group was lower than that in control group (P < 0.05), the blood pressure level and smoking proportion of high risk population in intervention group were lower than in control group (P < 0.05), and the blood pressure, blood glucose control rate of chronic diseases patients in intervention group were higher than in control group (P < 0.05). Conclusion: Comprehensive intervention could prevent the rise of chronic diseases prevalence. The intervention is effective in reducing or halting risk factors of high risk population, particularly in controlling blood pressure, blood glucose of patients. We should establish government leading, department cooperation, social participation, longtime and classified comprehensive intervention mechanism of chronic diseases. We believe that whole population should control the risk factors, high risk population should early diagnosis and treatment, chronic diseases patients should normalized management, and it could be applied in other counties.

Study on Chronic Diseases Comprehensive Intervention in Baoji of Shaanxi Province in China