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The present study was aimed to observe the effects of urea ingestion, non-protein nitrogen, on the disorder of nitrogen metabolism with the L-carnitine contents using the blood, kidney, liver, and femoral muscle as markers. A total of 8 Japanese white rabbits were used in this experiment. They were fed a basal diet prepared for the control group and the nitrogen volume proportionated to one-third of CP 14%, was replaced with urea in the feed of the experimental group for 7 days. On the final day, the animals were fasted from the previous evening and sacrificed. Blood was collected into a test tube at the same time of the sacrifice and their heart, kidney, liver and femoral muscle were collected. The L-carnitine contents in each sample and the urea in the blood were determined. The results of the growth test showed that there was no significant difference. Furthermore, there was no significant difference in the contents of L-carnitine and urea in each sample. It was concluded that nitrogen replacement of the diet with urea, in the range of 1/3 of dietary protein, had neither effect on the maintenance of body weight nor nitrogen balance, including the de novo synthesis of L-carnitine.

L-Carnitine Contents in the Tissues of Rabbits Fed Urea as an Alternative of Dietary Protein