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Body mass is considered to be related with immune function in animals. Our aim was to test the hypothesis that cellular and innate immunity would be suppressed in high body mass of Siberian hamsters (Phodopus sungorus). Six heavier (high body mass, HBM) and six lighter (low body mass, LBM) hamsters were selected from 28 male hamsters. Body mass, body fat mass, wet spleen mass and blood glucose levels were significantly higher in the HBM group than in the LBM group. However, phytohaemagglutinin response, serum bacteria killing capacity and white blood cells did not differ between the two groups, suggesting cellular and innate immunity was not impaired in high body mass of hamsters. There was no correlation between cellular, innate immunity and body mass, body fat mass and glucose levels, suggesting cellular and innate immunity was not suppressed by higher body mass, body fat mass and glucose levels. In summary, cellular and innate immunity was not impaired in the HBM hamsters compared with the LBM hamsters.

High Body Mass Has No Effect on Cellular and Innate Immunity in Siberian Hamsters (<i>Phodopus sungorus</i>)