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Proceeding from natural amino acid L-asparagineand commercially available aldehydes a stereoselective synthesis was developedof (2S,4S)-2-alkyl(aryl)-3-(3-sulfanylpropanoyl)-6-oxohexahy- dropyrimidine-4-carboxylicacids, potential antihypertensive drugs, inhibitors of the angiotensin convertingenzyme.

Synthesis of (2S,4S)-2-Substituted-3- (3-Sulfanylpropanoyl)-6- Oxohexahydropyrimidine-4-Carboxylic Acids as Potential Antihypertensive Drugs