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We propose a new dual treatment strategy by venous ulcer, consisting in simultaneous modulation of matrix metalloproteinases (MMPs) and heat shock proteins (HSPs) in the wound. One treatment method which can efficiently modulate both these substances is based on the application of dual-frequency ultrasound (LDM). This strategy was checked in a pilot study on 10 patients with chronic venous ulcers and demonstrated excellent healing rate

Dual Treatment Strategy by Venous Ulcers: Pilot Study to Dual-Frequency Ultrasound Application