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A series of chitosan/attapulgite (CTS/APT) hybrid microspheres were prepared by a facile spray-drying technique. The developed hybrid microspheres were characterized by Fourier transform infrared spectra (FTIR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and the zeta potential. The encapsulation efficiency and in vitro controlled release properties of the microspheres for drug were evaluated using diclofenac sodium (DS) as a model drug. Results indicated that the introduction of APT into crosslinked CTS microspheres can achieve narrow size distribution and make them more uniform. The isoelectric point of the microspheres increased from 8.14 to 9.18 with increasing the content of APT to 10 wt.%. DS loaded in hybrid microspheres is hardly released in simulated gastric fluid, but quickly released in simulated intestinal fluid. The electrostatic interaction between hybrid microspheres and DS can improve the encapsulation efficiency and controlled release behavior of CTS/APT microspheres, and the release mechanism fits Fickian diffusion

Preparation, Characterization and Drug-Release Behaviors of Crosslinked Chitosan/Attapulgite Hybrid Microspheres by a Facile Spray-Drying Technique