English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The behavior of the 2006 ten Tusscher-Panfilov model of human ventricular myocytes under the impact of periodic excitation impulses was studied in the BeatBox simulation environment. The cardiomyocyte model has a limited susceptibility to an forced higher frequency excitation rhythm. A high-frequency excitation rhythm can be forced by gradually increasing the frequency of excitation impulses. The mechanism of defibrillation pulse impact consists of presumably prolonging the refractoriness of cardiomyocytes which undermines their susceptibility for a long time to a forced high-frequency rhythm of fibrillation, as a result for which they hinder the propagation of a fibrillation wave. This is the only mechanism of defibrillation that was identified during the simulation. The threshold energy of a depolarizing defibrillation pulse prolonging the refractoriness of the cardio-myocyte varies depending on a delay relative to the excitation impulse (the excitation cycle phase) in a wide range (the maximum value exceeds the minimum by several thousand times). The results show differences in the mechanisms of impact on a cardiomyocyte between an excitation impulse and a monophasic defibrillation pulse.

Study of the Impact of Rectangular Current Pulses on the Ten Tusscher-Panfilov Model of Human Ventricular Myocyte