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The effect of complete social deprivation in early postnatal ontogenesis on adult behavior in Wag/Rij rats with a genetic predisposition to the development of absence epilepsy was studied. From the 2nd to the 8th day of life, a 3-hour daily isolation of the pups from the mother and siblings was performed, the control animals were handled. In adulthood, offspring behavior was tested in an elevated plus-maze, an open field, and for an ability to learn the conditioned reflex of active avoidance. In isolated earlier rats, an increase in emotional reactivity, exploratory behavior in a potentially dangerous space, the speed of learning a conditioned reflex with negative painful reinforcement, and a disturbance of the formation of a defensive reaction were revealed. It is assumed that high emotional reactivity creates the prerequisites for the development of absence epilepsy.

Social Deprivation of Newborn Rats Modifies Exploratory and Defensive Behavior at Mature Age