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In the study, using ethanol extracts of Renshen (Panax ginseng C A Meyer), Xiyangshen (Panax quinquefolius L.) and Dangshen (Codonopsis pilosulae), we investigated the effect of these “Qi-invigorating” Chinese tonic herbs on mitochondrial ATP generation capacity (ATP-GC) in H9c2 cardiomyocytes in situ and rat hearts ex vivo. All three types of “Shens” stimulated mitochondrial ATP-GC, with Renshen being most potent. While a parallel enhancement in mitochondrial ATP-GC was observed in Renshen- and Xiyangshen-pretreated rats, Dangshen treatment did not produce detectable effect ex vivo. The discrepancy between in situ and ex vivo assays for Dangshen may be attributed by its limited oral-bioavailability to the heart. The tissue specific activity of Shens on mitochondrial ATP-GC may be explained by the “Meridian Theory” in traditional Chinese medicine

chinese medicine

“Qi-Invigorating” Chinese Tonic Herbs (&amp;lt;i&amp;gt;Shens&amp;lt;/i&amp;gt;) Stimulate Mitochondrial ATP Generation Capacity in H9c2 Cardiomyocytes &amp;lt;i&amp;gt;in Situ&amp;lt;/i&amp;gt; and Rat Hearts &amp;lt;i&amp;gt;ex Vivo&amp;lt;/i&amp;gt;