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Esfenvalerate belongs to the pyrethroid group of insecticides which display significant selective\udtoxicity against insects compared to mammalian species, nevertheless, they may pose health risks,\udespecially in case of accidental exposure. The aim of the present study was to model the effect of\udacute, relatively high-dose exposure of the esfenvalerate-containing formulation Sumi-Alpha®.\udEventual functional alterations in the central nervous system and in the gastrointestinal tract\udwere studied on in vitro tissue preparations at different delays after intragastric administration to\udrats. Neuronal effects were characterized by field potential recording in cortical and hippocampal\udbrain slices, while gastrointestinal effects were examined by analyzing the motility and excitability\udof isolated ileum segments. On the brain slices originating from esfenvalerate-treated animals,\udchanges in excitability of both inhibitory and excitatory type could be observed. Voltage thresholds\udnecessary to evoke responses in neocortex slices were elevated, and population spike amplitudes\udwere lower in hippocampal slices. However, epileptiform potentials with pronounced late\udcomponents were also observed. A decreased long-term potentiation (LTP) could be seen in both\udbrain areas after esfenvalerate treatment. Seizure susceptibility of the slices was not significantly\udaltered, but tended to be somewhat higher in slices originating from treated rats. In ileum segments,\udboth spontaneous and acetyl-choline (ACh)-elicited contractions were modified by treatment.\udEsfenvalerate raised the amplitude of contractions in the low ACh concentration range.\udHowever, the solvent xylene also considerably contributed to the detected changes. We can conclude\udthat a relatively high, single oral dose of Sumi-Alpha® exerted mild and temporary effects on\udthe elementary brain functions and intestine functions of the rat

Nervous System and Gastrointestinal Effects of the Insecticide Esfenvalerate on the Rat: An &lt;i&gt;Ex Vivo&lt;/i&gt; Study

Nervous System and Gastrointestinal Effects of the Insecticide Esfenvalerate on the Rat: An <i>Ex Vivo</i> Study