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The prevalence of osteoporosis and decline in renal function increases with age. Therefore, the coexistence rate of both these conditions rises in the elderly population. Abnormalities in mineral bone metabolism are major complications in chronic kidney disease (CKD). However, in elderly osteoporotic patients without a history of CKD, there are few reports on the relationship between calcium (Ca), phosphorus (P), and parathyroid hormone (PTH), and renal function. The purpose of this study was to investigate the relationship between Ca, P, and PTH, and renal function in elderly osteoporosis patients with no history of CKD. We evaluated 169 patients who had been treated for osteoporosis. The eGFR decreased with age resulting in a negative correlation (r = -0.514, p < 0.01). On the other hand, intact PTH increased with age resulting in an equilateral correlation (r = 0.202, p < 0.01). P increased, therefore Ca increased, resulting in an equalitarian correlation (r = 0.309, p < 0.01). In addition, an increase in intact PTH negatively correlated with a decrease in Ca and P (r = -0.403, p < 0.01 and r = -0.416, p < 0.01, respectively). Even if Ca and P are in the normal range, in case of a poor effect of an osteoporotic therapeutic drug, it is necessary to consider the measurement of intact PTH in elderly osteoporosis patients with no history of CKD.

advances in aging research

The Relationship of Serum Calcium, Phosphorus, and Parathyroid Hormone with Renal Function in Elderly Osteoporotic Patients with No History of Chronic Kidney Disease