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Tamoxifen was given orally to two groups of pregnant fe- male rats (0.4 mg/kg/day). First group before implantation -(day 1-3 post coitus), and the second after implantation (day -7-9 post coitus) with a control group given a saline only. After the last day of treat- ment blood samples were collected from the eye blood vessel of the females. The analysis of the gonadotrophin hormones (FSH, LH) and the sex hormones (Progesterone and Estrogen) were done by hor- mones kit. In both female groups (before and after implantation) the level of (FSH) was significantly decreased (P < 0.001; 4.22. ± 0.76 µl/ ml and p < 0.05; 1.79 ± 0.38 mlµ/ml respectively) as compared to the control group (16.11 ± 2.26 mlµ/ml and 3.28 ± 0.34 before and after implantation respectively). While in the second group (post implanta- tion) there were no significant effects of tamoxifen treatment on the levels of other hormones between both treated and control groups. There were some changes in hormone levels between the pre and post implantation, except the estrogen remain at the same level in all groups. The study indicates that tamoxifen acts differently (directly or indirectly) at the level of sex or gonadotrophin hormones.

Effect of Tamoxifen on the Level of the Gonadotrophins, Estrogenand Progesterone Hormones pre and post Implantation in the Rats