English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Suppressors of cytokine signaling (SOCS) are a family of intracellular proteins emerging as key physiological regulators of cytokine responses in fish innate immune system. In this study, the tissue-specific distribution indicated that PfSOCS1, 2 and 3 were expressed ubiquitously and differentially in eight examined tissues. The highest transcript levels of PfSOCS1 and 3 respectively expressed in gill and liver, while that of the PfSOCS2 appeared mainly in muscle, followed by head kidney. The temporal patterns of PfSOCSs were assessed through the experimental challenge of A. hydrophila or E. ictaluri, and their expressions were altered in liver, gill and head kidney. Concretely, western blotting and quantitative real-time PCR analyses showed that PfSOCSs were significantly up-regulated in the early stage and then decreased after A. hydrophila or E. ictaluri challenge. Furthermore, the innate immune response of PfSOCSs in gill was more sensitive than that in liver and head kidney. PfSOCSs played vital roles in response to A. hydrophila or E. ictaluri challenge in three essential immune-related tissues. Our findings suggested that PfSOCSs played crucial roles in innate immunity of P. fulvidraco, and provided useful evidence for further understanding on the modulation mechanism of PfSOCSs in the innate immune system of P. fulvidraco

Immune Responses of Three SOCS Genes in Yellow catfish (Pelteobagrus fulvidraco) Challenged with Aeromonas hydrophila or Edwardsiella ictaluri