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Different brands of volume-targeted modes may vary the location of tidal volume (V T ) monitoring and whether peak inspiratory pressure is adjusted based on inspiratory, expiratory , or leak-compensated V T . These variables may result in different levels of support provided to patients, especially when an endotracheal tube (ETT) leak is present. We hypothesized that there would be no differences in gas exchange, triggering, or work of breathing between volume-targeted modes of 3 different brands of equipment in a surfactant-deficient, spontaneously breathing animal model with and without an ETT leak.

Physiologic Effects of 3 Different Neonatal Volume-Targeted Ventilation Modes in Surfactant-Deficient Juvenile Rabbits