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Nebulized hypertonic saline is a highly effective therapy for patients with cystic fibrosis (CF), yet 10% of patients are intolerant of hypertonic saline administered via jet nebulizer. Positive expiratory pressure (PEP) nebulizers splint open the airways and offers a more controlled rate of nebulization.

Nebulized Hypertonic Saline Via Positive Expiratory Pressure Versus Via Jet Nebulizer in Patients With Severe Cystic Fibrosis