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OBJECTIVES  This study aimed to measure the association between the adiponectin, C1Q and collagen domain-containing ( ADIPOQ ) gene variants and obesity in Koreans.    METHODS  Three single nucleotide polymorphisms located in the  ADIPOQ  gene were genotyped in a population-based cross-sectional study of 986 healthy Koreans. Three different case-control groups (i.e. G1, G2, and G3) were defined according to body mass index (BMI) and serum adiponectin levels. Allelic and genotypic associations of this gene with obesity were measured using multivariate logistic regression analyses in each group.    RESULTS  The G allele of -11377C>G, a polymorphism located in the promoter region of the  ADIPOQ  gene (odds ratio (OR), 1.48; 95% confidence interval, 1.13-1.94) and most haplotypes including this allele significantly increased the risk for obesity. However, the OR decreased from 3.98 (G1 group) to 2.90 (G2 group) and 2.30 (G3 group) when a less strict definition of obesity was used. Most haplotypes, including this allele, significantly increased the risk of obesity. The statistical evidence from the GG genotype of -11377C>G (OR, 3.98) and the GT/GT diplotype composed of -11377G>C and +45T>G (OR, 5.20) confirmed the contribution of the G allele toward a predisposition for obesity.    CONCLUSION  These results suggest the contribution of the  ADIPOQ  gene toward susceptibility to obesity in healthy Koreans. The high-risk genotypes and haplotypes identified here may provide more information for identifying individuals who are at risk of obesity.

epidemiology and health

&amp;lt;italic&amp;gt;ADIPOQ&amp;lt;/italic&amp;gt; Gene Variants Associated with Susceptibility to Obesity and Low Serum Adiponectin Levels in Healthy Koreans