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Sporadic colorectal cancers with high-frequency microsatellite instability (MSI-H) are related to hypermethylation of mismatch repair (MMR) genes and a higher frequency of BRAF mutations than Lynch syndrome. We estimated the feasibility of hereditary colorectal cancer based on hMLH1 methylation and BRAF mutations.

annals of surgical treatment and research

<i>hMLH1</i>promoter methylation and<i>BRAF</i>mutations in high-frequency microsatellite instability colorectal cancers not fulfilling the revised Bethesda guidelines

hMLH1promoter methylation andBRAFmutations in high-frequency microsatellite instability colorectal cancers not fulfilling the revised Bethesda guidelines