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A series of 1-[(5-substituted phenyl)-4, 5-dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole derivatives (4a-j) have been synthesized by the reaction of 1-(5-substitutedphenyl-1H-tetrazol-1-yl) prop-2-en-1-one (3a-j) with hydrazine hydrate in acetic acid under reflux for 5 h. Structure of the synthesized compounds was established by their spectral data. As a new strategy for alleviating the oxidative damage in Diabetes mellitus, a growing interest has been observed in the usage of antioxidants. The synthesized compounds were screened for their in vitro antioxidant activity by DPPH free radical scavenging method and in vivo antidiabetic activity by streptozotocin-induced model. Compounds 4b, 4g, 4h and 4j were exhibit prominent antioxidant as well as antidiabetic activity. Compound 4i was exhibit moderate antidiabetic activity.

Synthesis, Antioxidant and Antidiabetic Activity of 1-[(5-Substituted phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole