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A 26year old Caucasian woman of Bulgarian descent presented at our department with multiple disseminated hypopigmented macules on the trunk and extremities since more than 4 years (Figure 1A). The differential diagnosis included: vitiligo, pityriasis vesicolor and Mycosis fungoideshypopigmented type. A punch biopsy was performed and histological examination revealed exocytosis of atypical lymphocytes with larger hyperchromic nuclei (Figure 1B). A punch biopsy from normally looking skin was taken and the histological and immunohistochemical examination showed pigment incontinence and epidermotropisme of single atypical, CD3+CD4+ lymphocytes. Clinical and histological diagnosis of Mycosis fungoideshypopigmented variant has been established.

Clinical, Histological and Immunohistochemical Changes in Hypopigmented Mycosis Fungoides in Response to Narrow-Band UVB Phototherapy