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Most of the physiological functions of human body vary daily and this variation leads to changes in diseased state and in plasma drug concentration also. Due to the peak level of hormones in the body leads to disturbed sleep and increased pain. Human sleep activity cycle or solar/lunar adaptations depends on circadian rhythm and influenced by individual’s genetic makeup is responsible to affect the physiological functions [1].

Chronotherapeutics: A Novel Approach in the Pharmacotherapy of Various Diseases