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Backgroundi¼Stress Cardiomyopathy (SCM) is an increasingly reported disease as a syndrome of acute, severe, but reversible, which is commonly triggered by an acute strong physical or emotional stress. But little is known whether chronic diseases may contribute to the occurrence of SCM. Methodi¼The case reports about SCM from January 1998 to May 2014 were searched in the PubMed using the Medical Subject Headings: “tako-tsubo cardiomyopathy” or “stress cardiomyopathy” or ‘‘ampulla syndrome’’ or ‘‘apical ballooning syndrome’’ or ‘‘broken heart syndrome’’. The publications were excluded which didn’t meet the inclusion criteria. SCM patients with and without chronic diseases were CD group and NCD group, respectively. The CD group was further classified into nine subgroups according to underlying chronic diseases. The circulatory diseases group which had the highest percentage in CD group was analyzed further. Results: 1331 literatures about SCM were collected, in which 1052 documents were eligible. In these documents, 1206 patients were reported, 795 had chronic diseases, 411 had no significant past medical history. The average age in NCD group was younger than that in CD group (57.3 ± 0.9 years versus 62.4 ± 0.6 years, P < 0.01). The number of SCM patients with Circulatory diseases was the most, then was Endocrine, Digestive, Respiratory, etc. The proportion of hypertension was 74.0% in circulatory diseases followed by dyslipidemia 29.3%, arrhythmia 10.1%, coronary artery disease 5.8%, etc. Conclusioni¼According to our results, the chronic diseases, especially hypertension, rose the rate of occurrence and delayed the onset age of SCM.

Stress Cardiomyopathy was Prone to Occur in Patients with Chronic Diseases: Maybe a Good Thing